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KMID : 0364820170530040304
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Korean Journal of Microbiology
2017 Volume.53 No. 4 p.304 ~ p.308
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Selection of model viruses for foot-and-mouth disease virus-related-experiments
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Kim Tae-Hwan
Thilina U. B. Herath
Kim Jae-Hoon
Lee Kwang-Nyeong
Park Jong-Hyeon
Kim Chul-Joong
Lee Jong-Soo
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Abstract
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Researchers have comparatively fewer opportunities to conduct experiments on foot-and-mouth disease virus (FMDV), owing to the limited availability of biosafety level 3 facilities. Bovine rhinovirus (BRV) and human rhinovirus (HRV), which are genetically closely related to FMDV, have been evaluated in this study as model viruses for FMDV. To discover whether BRV and HRV have similar physicochemical properties as FMDV, virus susceptibility tests have been performed in different physical (pH and heat) and chemical (acidic/alkaline solutions and commercial disinfectants) conditions in vitro. Our data revealed that the physicochemical characteristics of BRV and HRV were nearly similar to those of FMDV.
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KEYWORD
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bovine rhinovirus, FMDV-like virus, foot-andmouth disease virus, human rhinovirus, model viruses
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